P05.14 Minimum inhibitory concentrations of metronidazole and tinidazole againsttrichomonas vaginalis
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چکیده
منابع مشابه
In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.
The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of ...
متن کاملConcentrations of metronidazole and tinidazole in male genital tissues.
The steady-state concentrations of metronidazole and tinidazole in male genital tissues were analyzed in patients subjected to elective gonadal surgery. The nitroimidazoles were administered orally at 500 mg every 8 h, beginning 5 days before the operation. Eight hours after the last dose, the concentrations of tinidazole were 24.1 +/- 2.5 micrograms (mean +/- standard error of the mean)/g of p...
متن کاملPrevalence of Trichomonas vaginalis isolates with resistance to metronidazole and tinidazole.
Clinical isolates of Trichomonas vaginalis were obtained from women consecutively enrolled in a study of partner notification. Testing of susceptibility to metronidazole and tinidazole was performed. Resistance to metronidazole and tinidazole was present in 17/178 (9.6%) and 1/178 (0.56%) strains, respectively. In vitro resistance was poorly correlated with clinical response to treatment.
متن کاملIn vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis.
Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients...
متن کاملDetermination of minimum inhibitory concentrations.
Minimum inhibitory concentrations (MICs) are defined as the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation, and minimum bactericidal concentrations (MBCs) as the lowest concentration of antimicrobial that will prevent the growth of an organism after subculture on to antibiotic-free media. MICs are used by diagnostic la...
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ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 2015
ISSN: 1368-4973,1472-3263
DOI: 10.1136/sextrans-2015-052270.300